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Title: I-2/tbhp Mediated Diastereoselective Synthesis of Spiroaziridines
Authors: Ashitha, K T
Vinaya, P P
Krishna, A
Vincent, D C
Jalaja, R
Varughese, S
Somappa, S B
Keywords: TBHP
Issue Date: 4-Feb-2020
Publisher: Royal Society of Chemistry
Citation: Organic & Biomolecular Chemistry; 18(8):1588-1593
Abstract: Eventhough spiroheterocycles are considered as emerging drug candidates, synthesis of spiroaziridines has not been well explored so far. Herein, we disclose an efficient I2/TBHP mediated diastereoselective synthesis of N-alkyl spiroaziridines from primary amines and easily accessible α,β-unsaturated ketones. The reaction is also compatible for the synthesis of 2-aroylaziridines.
Appears in Collections:2020

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