Pyridine core activation via 1,5-electrocyclization of vinyl pyridinium ylides generated from bromo isomerized Morita-Baylis-Hillman adduct of isatin and pyridine: Synthesis of 3-spirodihydroindolizine oxindoles

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Title:	Pyridine core activation via 1,5-electrocyclization of vinyl pyridinium ylides generated from bromo isomerized Morita-Baylis-Hillman adduct of isatin and pyridine: Synthesis of 3-spirodihydroindolizine oxindoles
Authors:	Baby Viswambharan Selvakumar, K Suchithra, M Shanmugam, P
Keywords:	Analogs Cycloaddition Natural-products Alkaloids Spirotryprostatin-A Efficient synthesis Stereocontrolled synthesis Stereoselective-synthesis Azomethine ylides Asymmetric total-synthesis
Issue Date:	2010
Publisher:	American Chemical Society
Citation:	Organic Letters 12(9):2108-2111;07 May 2010
Abstract:	An activation of the pyridine nucleus has been achieved via 1,5-electrocyclization of vinyl pyridinium ylides generated from bromo isomerized Morita-Baylis-Hillman adducts of isatin and pyridine under basic conditions. The method has been successfully Applied for an efficient synthesis of a number of 3-spirodihydroindolizine-2-oxindoles, which have been found as core structure of secoyohimbane and heteroyohimbane alkaloid natural products.
URI:	http://ir.niist.res.in:8080/jspui/handle/123456789/1007
ISSN:	1523-7060
Appears in Collections:	2010

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