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Title: Pyridine core activation via 1,5-electrocyclization of vinyl pyridinium ylides generated from bromo isomerized Morita-Baylis-Hillman adduct of isatin and pyridine: Synthesis of 3-spirodihydroindolizine oxindoles
Authors: Baby Viswambharan
Selvakumar, K
Suchithra, M
Shanmugam, P
Keywords: Analogs
Cycloaddition
Natural-products
Alkaloids
Spirotryprostatin-A
Efficient synthesis
Stereocontrolled synthesis
Stereoselective-synthesis
Azomethine ylides
Asymmetric total-synthesis
Issue Date: 2010
Publisher: American Chemical Society
Citation: Organic Letters 12(9):2108-2111;07 May 2010
Abstract: An activation of the pyridine nucleus has been achieved via 1,5-electrocyclization of vinyl pyridinium ylides generated from bromo isomerized Morita-Baylis-Hillman adducts of isatin and pyridine under basic conditions. The method has been successfully Applied for an efficient synthesis of a number of 3-spirodihydroindolizine-2-oxindoles, which have been found as core structure of secoyohimbane and heteroyohimbane alkaloid natural products.
URI: http://ir.niist.res.in:8080/jspui/handle/123456789/1007
ISSN: 1523-7060
Appears in Collections:2010

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