Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1048
Title: Transition metal catalyzed carboannulation of diazabicyclic alkenes with ambiphilic bifunctional reagents: A facile route towards functionalized indanones and indanols
Authors: Nayana Joseph
Jubi John
Rani, R
Sreeja, T
Anupa, M
Suresh, E
Radhakrishnan, K V
Keywords: Arylboron compounds
Cyclic carbopalladation
Alkylidene cyclopentenes
Enantioselective desymmetrization
Efficient synthesis
Annulation reactions
Stereoselective-synthesis
Meso bicyclic hydrazines
Substituted aryl halides
Indanones
Boronic acids
Transition metals
Carboannulation
Diazabicyclic alkenes
Issue Date: 2011
Publisher: Elsevier
Citation: Tetrahedron 67(26):4905-4913;01 Jul 2011
Abstract: Functionalized indanones are readily prepared in good to excellent yields by the Pd/Rh catalyzed carboannulation of bicyclic and tricyclic hydrazines with 2-iodobenzonitrile, 2-cyanophenylboronic acid and 2-formylphenylboronic acid. The reaction with 2-formylphenylboronic acid afforded 3,4-disubstituted cyclopentenes as minor product along with indanones under Rh catalyzed conditions, whereas indanols were obtained as the major product under Pd catalyzed conditions. The products obtained can be synthetically manipulated easily to pharmaceutically important molecules.
URI: http://ir.niist.res.in:8080/jspui/handle/123456789/1048
ISSN: 0040-4020
Appears in Collections:2011

Files in This Item:
File Description SizeFormat 
2011_ 0072.pdf1.18 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.