Transition metal catalyzed carboannulation of diazabicyclic alkenes with ambiphilic bifunctional reagents: A facile route towards functionalized indanones and indanols

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Title:	Transition metal catalyzed carboannulation of diazabicyclic alkenes with ambiphilic bifunctional reagents: A facile route towards functionalized indanones and indanols
Authors:	Nayana Joseph Jubi John Rani, R Sreeja, T Anupa, M Suresh, E Radhakrishnan, K V
Keywords:	Arylboron compounds Cyclic carbopalladation Alkylidene cyclopentenes Enantioselective desymmetrization Efficient synthesis Annulation reactions Stereoselective-synthesis Meso bicyclic hydrazines Substituted aryl halides Indanones Boronic acids Transition metals Carboannulation Diazabicyclic alkenes
Issue Date:	2011
Publisher:	Elsevier
Citation:	Tetrahedron 67(26):4905-4913;01 Jul 2011
Abstract:	Functionalized indanones are readily prepared in good to excellent yields by the Pd/Rh catalyzed carboannulation of bicyclic and tricyclic hydrazines with 2-iodobenzonitrile, 2-cyanophenylboronic acid and 2-formylphenylboronic acid. The reaction with 2-formylphenylboronic acid afforded 3,4-disubstituted cyclopentenes as minor product along with indanones under Rh catalyzed conditions, whereas indanols were obtained as the major product under Pd catalyzed conditions. The products obtained can be synthetically manipulated easily to pharmaceutically important molecules.
URI:	http://ir.niist.res.in:8080/jspui/handle/123456789/1048
ISSN:	0040-4020
Appears in Collections:	2011

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