Palladium-catalyzed bis-functionalization of isatylidenes: A facile route towards spiro-indol-2-ones

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Title:	Palladium-catalyzed bis-functionalization of isatylidenes: A facile route towards spiro-indol-2-ones
Authors:	George, S C Jubi John Anas, S Joshni John Yamamoto, Y Suresh, E Radhakrishnan, K V
Keywords:	Allylation Palladium Nitrogen heterocycles Spiro compounds
Issue Date:	2010
Publisher:	Wiley
Citation:	European Journal of Organic Chemistry (28):5489-5497;Oct 2010
Abstract:	An effective protocol has been developed for the construction of 3,3-disubstituted indol-2-ones from isatylidenes by utilizing amphiphilic bis-pi-allylpalladium and related intermediates. The developed strategy is a new method for the quaternization of position 3 of the indol-2-one towards disubstituted functionalized indol-2-ones. These products were subjected to ring-closing metathesis towards the synthesis of spiro[cyclohexene-1,3 '-indol]-2 '-ones and spiro[oxep-5-ene-2,3 '-indol]-2 '-ones, which are of biological interest.
URI:	http://ir.niist.res.in:8080/jspui/handle/123456789/1246
ISSN:	1434-193X
Appears in Collections:	2010

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