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|Title:||Palladium-catalyzed bis-functionalization of isatylidenes: A facile route towards spiro-indol-2-ones|
|Authors:||George, S C|
Radhakrishnan, K V
|Citation:||European Journal of Organic Chemistry (28):5489-5497;Oct 2010|
|Abstract:||An effective protocol has been developed for the construction of 3,3-disubstituted indol-2-ones from isatylidenes by utilizing amphiphilic bis-pi-allylpalladium and related intermediates. The developed strategy is a new method for the quaternization of position 3 of the indol-2-one towards disubstituted functionalized indol-2-ones. These products were subjected to ring-closing metathesis towards the synthesis of spiro[cyclohexene-1,3 '-indol]-2 '-ones and spiro[oxep-5-ene-2,3 '-indol]-2 '-ones, which are of biological interest.|
|Appears in Collections:||2010|
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