Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/1246
Title: Palladium-catalyzed bis-functionalization of isatylidenes: A facile route towards spiro-indol-2-ones
Authors: George, S C
Jubi John
Anas, S
Joshni John
Yamamoto, Y
Suresh, E
Radhakrishnan, K V
Keywords: Allylation
Nitrogen heterocycles
Spiro compounds
Issue Date: 2010
Publisher: Wiley
Citation: European Journal of Organic Chemistry (28):5489-5497;Oct 2010
Abstract: An effective protocol has been developed for the construction of 3,3-disubstituted indol-2-ones from isatylidenes by utilizing amphiphilic bis-pi-allylpalladium and related intermediates. The developed strategy is a new method for the quaternization of position 3 of the indol-2-one towards disubstituted functionalized indol-2-ones. These products were subjected to ring-closing metathesis towards the synthesis of spiro[cyclohexene-1,3 '-indol]-2 '-ones and spiro[oxep-5-ene-2,3 '-indol]-2 '-ones, which are of biological interest.
ISSN: 1434-193X
Appears in Collections:2010

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