A facile synthesis of novel triazabicyclic molecules as potential bicyclic templates for pharmaceutical ligands by the ring opening metathesis-cross metathesis of triazatricyclo[3.2.1.0(2,6)]dec-8-ene-3,5-diones

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Title:	A facile synthesis of novel triazabicyclic molecules as potential bicyclic templates for pharmaceutical ligands by the ring opening metathesis-cross metathesis of triazatricyclo[3.2.1.0(2,6)]dec-8-ene-3,5-diones
Authors:	Anas, S Sarika, C Rani, R Radhakrishnan, K V
Keywords:	Ring opening metathesis-cross metathesis Grubb's catalyst Triazoline-diones Triazabicyclic molecules Peptide backbone geometry Side-chain functionality Domino metathesis Olefin metathesis Amino-acids Thrombin inhibitors Mimetics Organic-synthesis
Issue Date:	2008
Publisher:	CSIR
Citation:	Indian Journal of Chemistry Section B-Organic Chemistry Including Medicinal Chemistry 47(7):1063-1070;Jul 2008
Abstract:	Novel multifunctional triazabicyclic molecules are synthesized in excellent yields by the ring opening metathesis-cross metathesis of triazatricyclo [3.2.1.0(2,6)]dec-8-ene-3,5-diones with various terminal olefins. The rigid synthesized molecules can be used as potential bicyclic templates for a number of pharmaceutically important ligands.
URI:	http://ir.niist.res.in:8080/jspui/handle/123456789/1378
ISSN:	0376-4699
Appears in Collections:	2008

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