Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/1454
Title: Synthesis of novel zerumbone derivatives via regioselective palladium catalyzed decarboxylative coupling reaction: a new class of alpha-glucosidase inhibitors
Authors: Ajish, K R
Dhanya, B P
Nayana Joseph
Priya Rani, M
Raghu, K G
Vineetha, V P
Radhakrishnan, K V
Keywords: Zerumbone
Zingiber zerumbet
Palladium
Decarboxylative coupling
Alpha-Glucosidase inhibitors
Issue Date: 2014
Publisher: Elsevier Science
Citation: Tetrahedron Letters 55(3):665-670;15 Jan 2014
Abstract: A new strategy for the synthesis of novel zerumbone derivatives via a regioselective palladium catalyzed decarboxylative coupling reaction using arene carboxylic acids is described. The current methodology involves the repositioning of endocyclic double bond to exocyclic double bond of zerumbone. Preliminary in vitro analysis revealed that most of the newly synthesized derivatives are potent alpha-glucosidase enzyme inhibitors.
URI: http://ir.niist.res.in:8080/jspui/handle/123456789/1454
ISSN: 0040-4039
Appears in Collections:2014

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