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|Title:||Rhodium(III) catalyzed synthesis of isoquinolone fused azabicycles through C-H activation of N-pivaloyloxy benzamides|
Aparna, P S
Radhakrishnan, K V
|Citation:||Tetrahedron Letters 55(4):916–920;22 Jan 2014|
|Abstract:||Herein we describe an efficient one pot strategy toward highly functionalized isoquinolone fused azabicycles having great synthetic potential via C-H activation of N-pivaloyloxy benzamides under very mild conditions. The reaction is accomplished at room temperature within one hour in good to excellent yields and is found to be compatible with a range of diazabicyclic olefins and benzamides. The present strategy offers an easy route for the synthesis of biologically relevant compounds which possess multiple points for divergent synthesis. N-N bond cleavage of synthesized compounds may enable their significant role as effective precursors for the preparation of diaminocyclopentane fused isoquinolones.|
|Appears in Collections:||2014|
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