Cytotoxicity studies of semi-synthetic derivatives of theveside derived from the aqueous extract of leaves of 'suicide tree' Cerbera odollam

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Title:	Cytotoxicity studies of semi-synthetic derivatives of theveside derived from the aqueous extract of leaves of 'suicide tree' Cerbera odollam
Authors:	Gorantla, J N Jamsheena, V Lekshmi R Nath Anto, R J Ravi S Lankalapalli
Keywords:	Cerbera odollam Theviridoside Theveside Semi-synthetic derivatives
Issue Date:	2014
Publisher:	Taylor & Francis
Citation:	Natural Product Research 28(18):1507-1512;2014
Abstract:	We report the isolation of two known iridoid glucosides theviridoside (1) and theveside (2) from the aqueous extract of leaves of Cerbera odollam and semi-synthetic derivatisation of theveside prepared in a single step under protection group-free conditions. Derivatives 2a-j were evaluated for cytotoxicity towards five human cancer cell lines of different origins, namely SKBR3 (breast), HeLa (cervical), A375 (skin), HepG2 (liver) and HCT-116 (colon), and IC50 values were determined. Derivatives 2b and 2h exhibited moderate cytotoxicity against HCT-116 and A375 cell lines, respectively.
URI:	http://ir.niist.res.in:8080/jspui/handle/123456789/1662
ISSN:	1478-6419
Appears in Collections:	2014

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