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Title: Novel 1,3-dipolar cycloaddition reactions of calix[4]bis(spirodienones): synthesis of isoxazolidine derived macrocycles
Authors: Ganga, V B
Suresh, E
Luxmi Varma, R
Keywords: Calix[4]bis(spirodienone)
1,3-dipolar cycloaddition
Issue Date: 2008
Publisher: Elsevier
Citation: Tetrahedron Letters 49(11):1750-1752;10 Mar 2008
Abstract: Calix [4]bis(spirodienones) can perform as either 4 pi or 2 pi components in cycloaddition reactions with various carbo- and heterodienophiles and with 1,2-benzoquinones leading to the formation of highly functionalized macrocycles. In this Letter we report, highly regio- and stereoselective 1,3-dipolar cycloaddition reactions of a bis(spirodienone) derivative of calix[4]arene with nitrones that provide easy access to isoxazolidine derived macrocycles in excellent yields. These isoxazolidine derivatives can be considered as direct precursors of 1,3-amino alcohols.
ISSN: 0040-4039
Appears in Collections:2008

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