Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/2017
Title: Tandem organocatalyzed Knoevenagel condensation/1,3-dipolar cycloaddition towards highly functionalized fused 1,2,3-triazoles
Authors: Jubi John
Joice Thomas
Parekh, N
Dehaen, W
Keywords: Organocatalysis
Tandem reactions
Nitrogen heterocycles
Issue Date: 2015
Publisher: Wiley-V C H
Citation: European Journal of Organic Chemistry 2015(22):4922-4930;Aug 2015
Abstract: Facile synthesis of fused 1,2,3-triazoles by a proline-catalyzed reaction of an azido aldehyde and a nitroalkane is elaborated. The present tandem protocol proceeds via an organocatalytic Knoevenagel condensation of the azido aldehyde and nitroalkane followed by intramolecular azidenitroalkene cycloaddition. The functionalized bicyclic tri-azole is obtained by elimination of HNO2 from the cycloadduct. Application of this strategy enabled us to synthesize a range of functionalised 5-7 membered ring fused triazoles. The reaction calls for mild conditions, affords high yields, and results in good regiospecificity while displaying excellent substrate scope.
ISSN: 1434-193X
Appears in Collections:2015

Files in This Item:
File Description SizeFormat 
  Restricted Access
1.21 MBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.