Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/2031
Title: Hydrophobic grafted and cross-linked starch nanoparticles for drug delivery
Authors: Simi, C K
Emilia Abraham, T
Keywords: Chemical modification
Grafting
Cross-linking
Nanoparticle
Controlled drug release
Issue Date: 2007
Publisher: Springer
Citation: Bioprocess and Biosystems Engineering 30(3):173-180;May 2007
Abstract: The synthesis of modified hydrophobic starch nanoparticles using long chain fatty acids was accomplished. Grafting of fatty acid on the starch was done using potassium persulphate as catalyst and the formation of graft polymer was confirmed by FTIR spectra. The thermal properties of the native and grafted starch were investigated using simultaneous TG-DTA and DSC. The graft polymerization was found to be depending on the temperature and the duration of the reaction. The modified starch nanoparticles were cross-linked with sodium tripoly phosphate for better stabilization. Morphology of the grafted starch nanoparticles was studied by SEM and AFM. Drug-loading and the controlled release of the drug from the nanoparticles was studied using indomethacin as model drug.
URI: http://ir.niist.res.in:8080/jspui/handle/123456789/2031
ISSN: 1615-7591
Appears in Collections:2007

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