Palladium catalyzed ring opening of azabicyclic olefins with organoindium and gallium reagents: a facile access towards benzylated cyclopentanoids

Abstract

Palladium catalyzed desymmmetrization of diazabicyclic olefins with organoindium and gallium reagents were examined These reactions provided an easy access to trans-3,4-disubstituted cyclopentenes in good to excellent yields Indium reagents exhibited better reactivity compared to gallium reagents The developed methodology demonstrates a simple. clean and efficient route towards substituted cyclopentenes The present strategy provides access to benzylated cyclopentene derivatives in one pot, which forms the skeleton of a number of biologically important molecules