Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/2148
Title: Palladium/Lewis acid-catalyzed reactions of bicyclic hydrazines with organostannanes: A general methodology for the stereoselective synthesis of 3,4-disubstituted cyclopentenes
Authors: Sajisha, V S
Radhakrishnan, K V
Keywords: Bicyclic hydrazines
Disubstituted cyclopentenes
Homogeneous catalysis
Organostannanes
Palladium
Aminocyclopentitol glycosidase inhibitors
Structure elucidation
Mannostatin-A
Microorganisms
Metabolites
Antibiotics
Derivatives
Chemistry
Issue Date: 2006
Publisher: Wiley
Citation: Advanced Synthesis and Catalysis 348(7-8):924-930
Abstract: Pd/Lewis acid-catalyzed reactions of bicyclic hydrazines with organostannanes afforded the 3,4-disubstituted cyclopentenes in excellent yields. The reaction is milder and is the first general methodology developed for the stereoselective synthesis of trans, vicinal disubstituted cyclopentenes. The results show that organostannanes with easily functionalizable moieties can be efficiently utilized in the ring opening of bicyclic hydrazines leading to the stereoselective formation of 3,4-disubstituted cyclopentenes. The products, having a wide range of substituents, are important intermediates in the synthesis of biologically active molecules like cyclopentenyl nucleosides, glycosidase inhibitors etc.
URI: http://ir.niist.res.in:8080/jspui/handle/123456789/2148
ISSN: 1615-4150
Appears in Collections:2006

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