Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/2421
Title: Reactive Oxygen Species (ROS) Mediated Enhanced Anti-Candidal Activity of ZnS-ZnO Nano-composites with Low Inhibitory Concentrations
Authors: Suyana, P
Kumar, S N
Nimisha, M
Dileep Kumar, B S
Nair, B N
Peer Mohamed, A
Warrier, K G K
Hareesh, U S
Issue Date: 2015
Publisher: Royal Society of Chemistry
Citation: RSC Advances, 5(94):76718-76728
Abstract: Enhanced antifungal activity against the yeast species Candida albicans, Candida tropicalis and Saccharomyces cerevisiae was displayed by ZnS–ZnO nanocomposites prepared by a simple precipitation technique. The antifungal activity was significantly more in the presence of indoor light than under dark conditions and was a clear confirmation of the inhibitory role of reactive oxygen species (ROS) generated in situ by the photocatalytic nanocomposites. The generation of ROS was further evidenced by flow cytometry results and membrane permeabilisation studies. Time kill assay and growth curve analysis indicated diminished antifungal activity under dark conditions due primarily to Zn2+ efflux in solution.
Appears in Collections:2015

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