CATALYTIC DESYMMETRIZATION OF DIAZABICYCLIC OLEFINS: A HIGHLY STEREOSELECTIVE STRATEGY TOWARDS FUNCTIONALIZED CYCLOPENTANOIDS

Abstract

One of the most important goals in contemporary synthetic organic chemistry is the development of stereoselective carbon–carbon coupling reactions providing a broadly applicable method to synthesize complex structures from simple precursors. Skeletal rearrangements of such simple precursors are powerful processes for generating molecular diversity with atom economy. In this context, desymmetrization of meso compounds provides an efficient route to asymmetric synthons of high value in a limited number of steps