p‑TSA/Base-Promoted Propargylation/Cyclization of β‑Ketothioamides for the Regioselective Synthesis of Highly Substituted (Hydro)Thiophenes

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DC Field	Value	Language
dc.contributor.author	Ganesh Chandra Nandi	-
dc.contributor.author	Maya Shankar, Singh	-
dc.date.accessioned	2017-06-22T11:07:11Z	-
dc.date.available	2017-06-22T11:07:11Z	-
dc.date.issued	2016-06-21	-
dc.identifier.citation	Journal of organic Chemistry 81:5824−5836	en_US
dc.identifier.uri	http://hdl.handle.net/123456789/2832	-
dc.description.abstract	Metal-free, p-toluenesulfonic acid (p-TSA)- mediated, straightforward propargylation of β-ketothioamides with aryl propargyl alcohol has been achieved at room temperature. In addition, the reaction also provided thiazole rings as byproducts. Furthermore, the propargylated thioamides undergo intramolecular 1,5-cyclization to afford fully substituted (hydro)thiophenes in the presence of base. Notably, the approach is pot, atom, and step economical (PASE)	en_US
dc.language.iso	en	en_US
dc.publisher	ACS publication	en_US
dc.subject	modulator	en_US
dc.subject	performing	en_US
dc.subject	formation	en_US
dc.subject	chloro-substituted	en_US
dc.title	p‑TSA/Base-Promoted Propargylation/Cyclization of β‑Ketothioamides for the Regioselective Synthesis of Highly Substituted (Hydro)Thiophenes	en_US
dc.type	Article	en_US
Appears in Collections:	2016

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