p‑TSA/Base-Promoted Propargylation/Cyclization of β‑Ketothioamides for the Regioselective Synthesis of Highly Substituted (Hydro)Thiophenes

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Title:	p‑TSA/Base-Promoted Propargylation/Cyclization of β‑Ketothioamides for the Regioselective Synthesis of Highly Substituted (Hydro)Thiophenes
Authors:	Ganesh Chandra Nandi Maya Shankar, Singh
Keywords:	modulator performing formation chloro-substituted
Issue Date:	21-Jun-2016
Publisher:	ACS publication
Citation:	Journal of organic Chemistry 81:5824−5836
Abstract:	Metal-free, p-toluenesulfonic acid (p-TSA)- mediated, straightforward propargylation of β-ketothioamides with aryl propargyl alcohol has been achieved at room temperature. In addition, the reaction also provided thiazole rings as byproducts. Furthermore, the propargylated thioamides undergo intramolecular 1,5-cyclization to afford fully substituted (hydro)thiophenes in the presence of base. Notably, the approach is pot, atom, and step economical (PASE)
URI:	http://hdl.handle.net/123456789/2832
Appears in Collections:	2016

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