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Title: Metal-Free Trans-Aziridination of Zerumbone: Synthesis and Biological Evaluation of Aziridine Derivatives of Zerumbone
Authors: Greeshma, G
Dhanya, B P
Saranya, J
Reshmitha, T R
Baiju, T V
Meenu, M T
Mangalam S Nair
Nisha, P
Radhakrishnan, K V
Keywords: Zerumbone
Hypervalent compounds
Nitrogen heterocycles
Small ring systems
Issue Date: 8-Jun-2017
Publisher: Wiley
Citation: European Journal of Organic Chemistry, (21):3072-3077
Abstract: Herein, we describe a metal-free, iodosobenzene diacetate mediated trans-aziridination of zerumbone by the direct use of sulfonamides. Preliminary in vitro screening showed that the synthesized compounds had better antiproliferative and antidiabetic activities than the parent compound zerumbone.
Appears in Collections:2017

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