Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/3090
Title: Sequential Ugi Reaction/Base-induced Ring Closing/IAAC Protocol Toward Triazolobenzodiazepine-fused Diketopiperazines and Hydantoins
Authors: Robby, V
Bamba, F
Jonas, W
Joice, T
Jeroen, J
Meervelt, L V
Jubi John
Wim, D
Keywords: benzodiazepine
azide–alkyne cycloaddition
Ugi reaction
Issue Date: 14-Mar-2018
Publisher: Beilstein-Institut
Citation: Beilstein Journal of Organic Chemistry, 14:626-633
Abstract: A practical three-step protocol for the assembly of triazolobenzodiazepine-fused diketopiperazines and hydantoins has been developed. The synthesis of these tetracyclic ring systems was initiated by an Ugi reaction, which brought together all necessary functionalities for further transformations. The Ugi adducts were then subjected to a base-induced ring closing and an intramolecular azide–alkyne cycloaddition reaction in succession to obtain highly fused benzodiazepine frameworks.
Appears in Collections:2018

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