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dc.contributor.authorRobby, V-
dc.contributor.authorBamba, F-
dc.contributor.authorJonas, W-
dc.contributor.authorJoice, T-
dc.contributor.authorJeroen, J-
dc.contributor.authorMeervelt, L V-
dc.contributor.authorJubi John-
dc.contributor.authorWim, D-
dc.date.accessioned2018-06-01T10:54:36Z-
dc.date.available2018-06-01T10:54:36Z-
dc.date.issued2018-03-14-
dc.identifier.citationBeilstein Journal of Organic Chemistry, 14:626-633en_US
dc.identifier.urihttp://10.10.100.66:8080/xmlui/handle/123456789/3090-
dc.description.abstractA practical three-step protocol for the assembly of triazolobenzodiazepine-fused diketopiperazines and hydantoins has been developed. The synthesis of these tetracyclic ring systems was initiated by an Ugi reaction, which brought together all necessary functionalities for further transformations. The Ugi adducts were then subjected to a base-induced ring closing and an intramolecular azide–alkyne cycloaddition reaction in succession to obtain highly fused benzodiazepine frameworks.en_US
dc.language.isoenen_US
dc.publisherBeilstein-Instituten_US
dc.subjectbenzodiazepineen_US
dc.subject2,5-diketopiperazineen_US
dc.subjecthydantoinen_US
dc.subjectintramolecularen_US
dc.subjectazide–alkyne cycloadditionen_US
dc.subjectUgi reactionen_US
dc.titleSequential Ugi Reaction/Base-induced Ring Closing/IAAC Protocol Toward Triazolobenzodiazepine-fused Diketopiperazines and Hydantoinsen_US
dc.typeArticleen_US
Appears in Collections:2018

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