Study on Liposomal Encapsulation of New Bodipy Sensitizers for Photodynamic Therapy

Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/3093

Title:	Study on Liposomal Encapsulation of New Bodipy Sensitizers for Photodynamic Therapy
Authors:	Gayathri, T Vijayalakshmi, A Sreejith, M Joshy Joseph Madhusudhana Rao, N Singh, S P
Keywords:	Bodipy, photodynamic therapy liposomes photosensitizer photocytotoxicity cancer
Issue Date:	4-Feb-2018
Publisher:	American Chemical Society
Citation:	ACS Medicinal Chemistry Letters, 9(4):323-327
Abstract:	We report a series of four efficient photosensitizers (PSs) based on a Bodipy core for photodynamic therapy (PDT). In the absence of hydrophilic functional groups, these PSs have been encapsulated in liposomes and examined for photocytotoxicity against human ovarian carcinoma cell line (SK-OV- 3). The IC50 values obtained are as low as 0.350 μM, which compete with the classical photosensitizer chlorine E6 (IC50 = 0.39 μM) under similar experimental conditions.
URI:	http://10.10.100.66:8080/xmlui/handle/123456789/3093
Appears in Collections:	2018

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