Please use this identifier to cite or link to this item: http://ir.niist.res.in:8080/jspui/handle/123456789/3102
Title: pH-Responsive Fluorescence Enhancement in Graphene Oxide-Naphthalimide Nanoconjugates: A Fluorescence Turn-On Sensor for Acetylcholine
Authors: Sreejith, M
Silja, A
Joshy Joseph
Keywords: enzymes
fluorescence
graphene
pH
sensors
Issue Date: 22-Aug-2017
Publisher: Wiley
Citation: Chemistry: A European Journal, 23(47):11404–11409
Abstract: A pH-sensitive, fluorescence “turn-on” sensor based on a graphene oxide–naphthalimide (GO–NI) nanoconjugate for the detection of acetylcholine (ACh) by monitoring the enzymatic activity of acetylcholinesterase (AChE) in aqueous solution is reported. These nanoconjugates were synthesized by covalently anchoring picolyl-substituted NI derivatives on the GO/reduced GO surface through a 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide/N-hydroxysuccinimide coupling strategy, and the morphological and photophysical properties were studied in detail. Synergistic effects of p–p interactions between GO and the NI chromophore, and efficient photoinduced electron- and energytransfer processes, were responsible for the strong quenching of fluorescence of these nanoconjugates, which were perturbed under acidic pH conditions, leading to significant enhancement of fluorescence emission. This nanoconjugate was successfully employed for the efficient sensing of pH changes caused by the enzymatic activity of AChE, thereby demonstrating its utility as a fluorescence turn-on sensor for ACh in the neurophysiological range.
URI: http://10.10.100.66:8080/xmlui/handle/123456789/3102
Appears in Collections:2017

Files in This Item:
File Description SizeFormat 
pH-Responsive Fluorescence Enhancement - Sreejith M - Chemistry A European Journal.pdf
  Restricted Access
1.94 MBAdobe PDFView/Open Request a copy


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.