Synthesis and In Vitro Evaluation of Zerumbone Pendant Derivatives: Potent Candidates for Anti-Diabetic and Anti-Proliferative Activities

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Title:	Synthesis and In Vitro Evaluation of Zerumbone Pendant Derivatives: Potent Candidates for Anti-Diabetic and Anti-Proliferative Activities
Authors:	Dhanya, B P Greeshma, G Reshmitha, T R Saranya, J Sharathna, P Shibi, I G Nisha, P Radhakrishnan, K V
Issue Date:	26-May-2017
Publisher:	Royal Society of Chemistry
Citation:	New Journal of Chemistry, 41(15):6960-6964
Abstract:	A series of zerumbone pendant derivatives were synthesized and evaluated for their a-glucosidase, a-amylase and glycation inhibition activities. In our study, some of the derivatives showed potent inhibitory activity in micromolar concentration. In addition, investigations were carried out to screen the cytotoxic effects of some selected derivatives against various cancer cell lines viz., A549, HCT116, HeLa, HT1080 and MDAMB231. Two of the derivatives showed potent activity towards HCT116 and HeLa cell lines.
URI:	http://10.10.100.66:8080/xmlui/handle/123456789/3111
Appears in Collections:	2017

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