Lewis Acid Promoted Regioselective Double Hydro(hetero)arylation of 6,6′-Dialkyl-Substituted Pentafulvenes: A Facile Approach to Bisindole Derivatives

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Title:	Lewis Acid Promoted Regioselective Double Hydro(hetero)arylation of 6,6′-Dialkyl-Substituted Pentafulvenes: A Facile Approach to Bisindole Derivatives
Authors:	Sasikumar, P Prabha, B Chand, S S Aswathy, M Madhukrishnan, M Preethanuj, P Suresh, E Jaroschik, F Radhakrishnan, K V
Keywords:	Fulvenes C–C coupling Hydro(hetero)arylation Lewis acids Nitrogen heterocycles
Issue Date:	17-Aug-2017
Publisher:	Wiley
Citation:	European Journal of Organic Chemistry, 2017(30):4469-4474
Abstract:	A Lewis acid catalyzed double hydro(hetero)arylation of alkyl-substituted pentafulvenes for the synthesis of bisindolesubstituted cyclopentenoids has been developed. The scope of the reaction was explored with a wide range of indoles and pentafulvenes, and mechanistic insights were obtained. In addi-tion, we have also demonstrated a hydro(hetero)arylation–dehydroxylation reaction of 2-hydroxy-substituted pentafulvenes to afford bisindole derivatives with isoprenyl-substituted cyclopentene moieties.
URI:	http://10.10.100.66:8080/xmlui/handle/123456789/3120
Appears in Collections:	2017

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