Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/3166
Title: Lewis-Acid-Catalyzed Activation of Zerumbone towards Sesquiterpenoid Derivatives: Sustainable Utilization of Abundant Natural Resources for the Synthesis of Chemically Diverse Architectures
Authors: Dhanya, B P
Greeshma, G
Sasikumar, P
Neethu, S
Meenu, M T
Sharathna, P
Jubi, John
Sunil, Varughese
Sabu, M
Dan, M
Radhakrishnan, K V
Keywords: cyclization
Lewis acids
natural products
sesquiterpenoids
zerumbone
Issue Date: 8-Jan-2018
Publisher: Wiley
Citation: Asian Journal of Organic Chemistry , 7:471 – 476
Abstract: A facile Lewis-acid-catalyzed method for the synthesis of structurally diverse sesquiterpenoid derivatives from readily available and abundant 11-membered natural product zerumbone has been developed. Starting from zerumbone, we have developed an efficient cyclization process for the creation of [5.7], [5.8], and [5.8.3] fused-ring systems. This process was exemplified by the selective functionalization of zerumbone; by controlling the conformation of the 11-membered ring, the ring-closing process could be tuned to afford the fused-ring system of choice.
URI: http://10.10.100.66:8080/xmlui/handle/123456789/3166
Appears in Collections:2018

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