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dc.contributor.authorSanthakumar, H-
dc.contributor.authorNair, R V-
dc.contributor.authorDivya, S P-
dc.contributor.authorShenoy, S J-
dc.contributor.authorAnoopkumar, T-
dc.contributor.authorAjayaghosh, A-
dc.contributor.authorJayasree, R S-
dc.date.accessioned2018-07-06T11:02:14Z-
dc.date.available2018-07-06T11:02:14Z-
dc.date.issued2018-07-01-
dc.identifier.citationScientific Reports, 8(1):9069en_US
dc.identifier.urihttp://10.10.100.66:8080/xmlui/handle/123456789/3168-
dc.description.abstractZinc, the essential trace element in human body exists either in the bound or free state, for both structural and functional roles. Insights on Zn2+ distribution and its dynamics are essential in view of the fact that Zn2+ dyshomeostasis is a risk factor for epileptic seizures, Alzheimer’s disease, depression, etc. Herein, a bipyridine bridged bispyrrole (BP) probe is used for ratiometric imaging and quantification of Zn2+ in hippocampal slices. The green fluorescence emission of BP shifts towards red in the presence of Zn2+. The probe is used to detect and quantify the exogenous and endogenous Zn2+ in glioma cells and hippocampal slices. The dynamics of chelatable zinc ions during epileptic condition is studied in the hippocampal neurons, in vitro wherein the translocation of Zn2+ from presynaptic to postsynaptic neuronal bodies is imaged and ratiometrically quantified. Raman mapping technique is used to confirm the dynamics of Zn2+ under epileptic condition. Finally, the Zn2+ distribution was imaged in vivo in epileptic rats and the total Zn2+ in rat brain was quantified. The results favour the use of BP as an excellent Zn2+ imaging probe in biological system to understand the zinc associated diseases and their management.en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.titleReal Time Imaging and Dynamics of Hippocampal Zn2+ Under Epileptic Condition Using a Ratiometric Fluorescent Probeen_US
dc.typeArticleen_US
Appears in Collections:2018

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