Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/3171
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dc.contributor.authorMohan, B-
dc.contributor.authorSalfeena, C T F-
dc.contributor.authorAshitha, K T-
dc.contributor.authorKrishnan, G V-
dc.contributor.authorAbdul Rasheed, S J-
dc.contributor.authorVargheese, A M-
dc.contributor.authorPatil, S A-
dc.contributor.authorDileep Kumar, B-
dc.contributor.authorSasidhar, B S-
dc.date.accessioned2018-07-09T09:53:18Z-
dc.date.available2018-07-09T09:53:18Z-
dc.date.issued2018-06-19-
dc.identifier.citationChemistrySelect, 3(23):6394-6398en_US
dc.identifier.urihttp://10.10.100.66:8080/xmlui/handle/123456789/3171-
dc.description.abstractFully substituted pyrimidine synthesis accomplished from alkynes and nitriles via BF3.Et2O mediated [2+2+2] cycloaddition. The substrate scope of the reaction was broad to include terminal alkynes to internal alkynes and aromatic nitriles to aliphatic nitriles furnished good to acceptable chemical yields. The marine alkaloid, meridianin analogs were synthesized successfully by utilizing this protocol. The pyrimidine analogues were also screened for their broad spectrum of antibacterial property against ten bacteria. Among the derivatives, 2,4 dimethyl-6-p-tolylpyrimidine (3b) has shown excellent inhibition potential against most of the tested organisms with a range of 9 to 21 mm zone of inhibition.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectAlkynesen_US
dc.subjectAntimicrobial agentsen_US
dc.subject[2+2+2] cycloadditionen_US
dc.subjectNitrilesen_US
dc.subjectPyrimidinesen_US
dc.titleFunctionalized Pyrimidines from Alkynes and Nitriles: Application towards the Synthesis of Marine Natural Product Meridianin Analogsen_US
dc.typeArticleen_US
Appears in Collections:2018

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