Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/3181
Title: Supramolecular Reassembly of Self-Exfoliated Ionic Covalent Organic Nanosheets for Label-Free Detection of Double-Stranded DNA
Authors: Arindam, Mal
Mishra, R K
Praveen, V K
Abdual Khayum, M
Banerjee, R
Ajayaghosh, A
Keywords: DNA
covalent organic framework
ionic assembly
ionic covalent organic nanosheets
label-free detection
Issue Date: 9-Jul-2018
Publisher: Wiley
Citation: Angewandte Chemie-International Edition, 57(28):8443-8447
Abstract: Ionic covalent organic nanosheets (iCONs), a member of the two-dimensional (2D) nanomaterials family, offer a unique functional platform for a wide range of applications. Herein, we explore the potential of an ethidium bromide (EB)-based covalent organic framework (EB-TFP) that self-exfoliates in water resulting in 2D ionic covalent organic nanosheets (EB-TFP-iCONs) for the selective detection of double-stranded DNA (dsDNA). In an aqueous medium, the self-exfoliated EB-TFP-iCONs reassemble in the presence of dsDNA resulting in hybrid EB-TFP-iCONs-DNA crystalline nanosheets with enhanced fluorescence at 600 nm. Detailed steady-state and time-resolved emission studies revealed that the reassembly phenomenon was highly selective for dsDNA when compared to single-stranded DNA (ssDNA), which allowed us to use the EB-TFP-iCONs as a 2D fluorescent platform for the label-free detection of complementary DNA strands.
URI: http://10.10.100.66:8080/xmlui/handle/123456789/3181
Appears in Collections:2018

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