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Title: Generation of e,e-Difluorinated Metal-Pentadienyl Species through Lanthanide-Mediated C@F Activation
Authors: Tarun Kumar
Massicot, F
Harakat, D
Chevreux, S
Martinez, A
Bordolinska, K
Preethanuj, P
Radhakrishnan, K V
Behr, J B
Vasse, J L
Jaroschik, F
Keywords: C-F activation
pentadienyl complexes
Issue Date: 21-Nov-2017
Publisher: Wiley
Citation: Chemistry - A European Journal, 23(65):16460–16465
Abstract: Heavy metal on Lewis acid: The combination of lanthanide metals and AlCl3 has been employed for selective single C@F activation in benzofulvenes comprising an exocyclic CF3 substituent. Intermediate e,e-difluorinated metal-dienyl species react with a large variety of aldehydes in a highly regio- and diastereoselective fashion to afford 1,1-disubstituted indenes bearing a difluorovinyl group. These new building blocks have been further transformed through a hydrogenation–cyclization process into fluorinated heterocyclic spiro compounds.
Appears in Collections:2017

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