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Title: One-Pot MCR-Oxidation Approach toward Indole-Fused Heteroacenes
Authors: Santhini, P V
Akhil Krishnan, R
Sheba Ann, B
Betna, S S
Das, G
Praveen, V K
Sunil Varughese
Jubi John
Issue Date: 14-Sep-2017
Publisher: American Chemical Society
Citation: The Journal of Organic Chemistry, 82(19):10537-10548
Abstract: A straightforward synthetic route toward indole-fused heteroacenes was developed. The strategy is composed of a one-pot process starting with a multicomponent reaction of cyclohexanone, primary amine and N-tosyl-3-nitroindole followed by an oxidation step. The onepot approach was found to be general, affording both symmetric and nonsymmetric indolo[3,2-b]indoles in good yields. The strategy was also utilized for accessing 5-ring fused benzo[g]indolo[3,2-b]indole. We could extend the methodology for the synthesis of benzothieno[3,2-b]indoles starting from 3-nitrobenzothiophene. The importance of the developed method was exemplified by performing the reaction sequence on gram scale and also by the synthetic transformations of indolo[3,2-b]indoles. In addition, the change in photophysical properties with extension of conjugation of the synthesized heteroacenes was studied.
Appears in Collections:2017

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