Recent topics of radical-based carbon-carbon bond formations

Abstract

Radical reactions have been a fascinating arena in organic chemistry for decades and the rapid progress in this field is the topic of this review. Generation of radicals through sustainable catalysis using photoredox catalysts and iron based catalysts have significantly expanded the scope of radical reactions for carbon–carbon and carbon-heteroatom bond formations in recent years. Selective transformations using silver salts and other single electron transfer oxidants have also played significant roles. Cascade reactions based on radical intermediates have even widened the potential of radical reactions for carbocyclic and heterocyclic constructions. The recent advances (2014–2017) in radical based methods for CAC bond formations are discussed in this digest review.