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dc.contributor.authorAnupama, N-
dc.contributor.authorSindhu, G-
dc.contributor.authorRaghu, K G-
dc.date.accessioned2018-07-30T06:59:52Z-
dc.date.available2018-07-30T06:59:52Z-
dc.date.issued2018-05-03-
dc.identifier.citationFundamental and Clinical Pharmacology, 32(4):346–356en_US
dc.identifier.urihttp://10.10.100.66:8080/xmlui/handle/123456789/3218-
dc.description.abstractMetabolic syndromes (MS) are a cluster of disorders such as obesity, hypertension, dyslipidemia, and diabetes. Cardiometabolic syndrome (CMS), a branch of MS, is a group of diseases affecting cardiovascular, renal, metabolic, prothrombotic, and inflammatory abnormalities due to defects in energy metabolism. Since the emergence of molecular biology and the discovery of pathogenic mitochondrial DNA defect in the 1980s, research advances have revealed a number of common human diseases involving mitochondrial dysfunction. One of the major defects in CMS and its associated diseases is excess cellular oxidative stress and oxidative damage to mitochondrial components. In this study, we overview specific aspects of mitochondrial biology that have contributed and likely will continue enhance the progress of development of therapeutics for CMS. During the last decade, however, increasing evidence has emerged supporting the role of mitochondrial functional parameters in the genesis of various metabolism-related disorders. The biochemical pathways which modulate various mitochondrial functional indicators such as mitochondrial biogenesis, mitochondrial membrane potential, electron transport chain and ATP synthesis, intramitochondrial oxidative stress, and mitochondria- mediated cell death have been recognized in diagnosis and prognosis of various disorders associated with energy metabolism and heart function.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectcalciumen_US
dc.subjectcardiolipinsen_US
dc.subjectFOXO3aen_US
dc.subjectmitochondriaen_US
dc.subjectreactive oxygen species,en_US
dc.subjectthioredoxinen_US
dc.titleSignificance of mitochondria on cardiometabolic syndromesen_US
dc.typeArticleen_US
Appears in Collections:2018

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