CuBr/TBHP-Mediated Synthesis of N-Acyl Sulfonimidamides Via the Oxidative Cross-coupling of Sulfonimidamides and Aldehydes

Abstract

N-Acyl sulfonimidamides were synthesized via a Cu-catalyzed double C–H/N–H activation protocol. The imino end of sulfonimidamides was acylated using aldehyde as the acylating agent and t-butyl hydrogen peroxide (TBHP) as the oxidant in acetonitrile (MeCN) at 82 °C. The mild reaction conditions afforded low-to-moderate yields of N-acyl sulfonimidamides with high structural diversity.