Synthesis of 1,2,4-Trisubstituted-(1H)‑imidazoles through Cu(OTf)2‑/ I2‑Catalyzed C−C Bond Cleavage of Chalcones and Benzylamines

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Title:	Synthesis of 1,2,4-Trisubstituted-(1H)‑imidazoles through Cu(OTf)2‑/ I2‑Catalyzed C−C Bond Cleavage of Chalcones and Benzylamines
Authors:	Salfeena, C T F Renjitha, J Davis, R Suresh, E Sasidhar, B S
Issue Date:	Jul-2018
Publisher:	American Chemical Society
Citation:	ACS Omega, 3(7):8074–8082
Abstract:	1,2,4-Trisubstituted-(1H)-imidazoles have been synthesized by the Cu(OTf)2- and I2-catalyzed unusual C−C bond cleavage of chalcones and benzylamines. After the α,β-unsaturated C−C bond cleavage, the β-portion is eliminated from the reaction. Various aryl- and heteroarylsubstituted chalcones and benzylamines were well tolerated in this unusual transformation to yield the trisubstituted-(1H)-imidazoles.
URI:	http://10.10.100.66:8080/xmlui/handle/123456789/3261
Appears in Collections:	2018

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