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Title: Chloroform as a carbon monoxide source in palladium-catalyzed synthesis of 2-amidoimidazo [1,2-a]pyridines
Authors: Nitha, P R
Manu, M
Greeshma, Gopalan
Maiti, K K
Radhakrishnan, K V
Das, Parthasarathi
Issue Date: Aug-2018
Publisher: The Royal Society of Chemistry
Citation: Organic & Biomolecular Chemistry, 16(35):6430–6437
Abstract: A palladium-catalyzed aminocarbonylation strategy exploiting chloroform as a CO source has been developed for the synthesis of biologically potent 2-amidoimidazopyridine scaffolds. The aminocarbonylation reaction was found to be general with a range of amines and substituted imidazopyridines. Preliminary biological evaluation of cytotoxicity on selected examples provides scope for future investigations.
Appears in Collections:2018

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