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dc.contributor.authorNair, V-
dc.contributor.authorMenon, R S-
dc.date.accessioned2019-06-28T10:47:32Z-
dc.date.available2019-06-28T10:47:32Z-
dc.date.issued2019-02-
dc.identifier.citationThe Chemical Record; 19(2-3):347–361en_US
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/abs/10.1002/tcr.201800027-
dc.identifier.urihttp://10.10.100.66:8080/xmlui/handle/123456789/3376-
dc.description.abstractA number of well‐known reactions, proceed through the intermediacy of dipolar/zwitterionic species generated via the addition of a neutral nucleophile with an unsaturated electrophile. A mechanistic understanding of these reactions was made possible by seminal contributions of Huisgen. The design of novel reactions based on such dipolar species was, however, not pursued in detail for a long time. Our efforts to exploit various reactivity profiles available for the zwitterionic/dipolar intermediates have resulted in the discovery of a large number of novel, convenient protocols to access a wide variety of products. The nucleophilic initiators may participate in the reaction or play a mediating role depending upon the nature of nucleophile, its quantity and the reaction conditions. In a majority of these transformations two electrophilic components, that would normally be inert towards each other, are combined by the intermediacy of a nucelophile. A brief summary of such nucleophile‐initiated novel reactions that were developed in our research group are described. Reactions involving a variety of nucleophiles such as phosphines, pyridine, quinoline, isoquinoline, isocyanides, dimethoxycarbene and N‐heterocyclic carbenes (NHCs) are discussed.en_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectMulticomponent reactionsen_US
dc.subjectOrganocatalysisen_US
dc.subjectZwitterions and Homoenolateen_US
dc.titleNucleophile‐Initiated Catalytic and Multicomponent Reactionsen_US
dc.typeArticleen_US
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