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Title: Nucleophile‐Initiated Catalytic and Multicomponent Reactions
Authors: Nair, V
Menon, R S
Keywords: Multicomponent reactions
Zwitterions and Homoenolate
Issue Date: 2-Jul-2018
Publisher: Wiley
Citation: The Chemical Record; 19(2-3):347 – 361
Abstract: A number of well‐known reactions, proceed through the intermediacy of dipolar/zwitterionic species generated via the addition of a neutral nucleophile with an unsaturated electrophile. A mechanistic understanding of these reactions was made possible by seminal contributions of Huisgen. The design of novel reactions based on such dipolar species was, however, not pursued in detail for a long time. Our efforts to exploit various reactivity profiles available for the zwitterionic/dipolar intermediates have resulted in the discovery of a large number of novel, convenient protocols to access a wide variety of products. The nucleophilic initiators may participate in the reaction or play a mediating role depending upon the nature of nucleophile, its quantity and the reaction conditions. In a majority of these transformations two electrophilic components, that would normally be inert towards each other, are combined by the intermediacy of a nucelophile. A brief summary of such nucleophile‐initiated novel reactions that were developed in our research group are described. Reactions involving a variety of nucleophiles such as phosphines, pyridine, quinoline, isoquinoline, isocyanides, dimethoxycarbene and N‐heterocyclic carbenes (NHCs) are discussed.
Appears in Collections:2018

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