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Title: Biosynthesis of 2,5-furan Dicarboxylic Acid by Aspergillus FLavus Apls-1: Process Optimization and Intermediate Product Analysis
Authors: Rajesh, R O
Godan, T K
Rai, A K
Sahoo, D
Pandey, A
Binod, P
Keywords: 2,5-furan dicarboxylic acid
Hydroxymethyl furfuraldehyde
Green bioprocess
Aspergillus flavus
Issue Date: 20-Mar-2019
Publisher: Elsevier
Citation: Bioresource Technology; 284:155-160
Abstract: The aim of the present study was to develop an eco-friendly biological process for the production of 2,5-furan dicarboxylic acid (FDCA) from 5-hydroxy methylfurfuraldehyde (HMF) using microorganisms. Microorganisms were isolated from the soil samples and evaluated for its biotransformation efficiency. Among the isolates, Aspergillus flavus APLS-1 was found to be potent for efficient conversion of HMF to FDCA. The bioconversion parameters were optimized by Box-Behnken design. The optimization resulted in 67% conversion efficiency where 1g/L HMF (8mM) was transformed to 0.83g/L (6.6mM) FDCA in 14days at pH6.5 with biomass size of 5.7g/L and biomass age 60h. This is the first report on Aspergillus sp., capable of detoxifying HMF and produces FDCA.
Appears in Collections:2019

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