Biosynthesis of 2,5-furan Dicarboxylic Acid by Aspergillus FLavus Apls-1: Process Optimization and Intermediate Product Analysis

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Title:	Biosynthesis of 2,5-furan Dicarboxylic Acid by Aspergillus FLavus Apls-1: Process Optimization and Intermediate Product Analysis
Authors:	Rajesh, R O Godan, T K Rai, A K Sahoo, D Pandey, A Binod, P
Keywords:	2,5-furan dicarboxylic acid Hydroxymethyl furfuraldehyde Biotransformation Green bioprocess Aspergillus ﬂavus
Issue Date:	20-Mar-2019
Publisher:	Elsevier
Citation:	Bioresource Technology; 284:155-160
Abstract:	The aim of the present study was to develop an eco-friendly biological process for the production of 2,5-furan dicarboxylic acid (FDCA) from 5-hydroxy methylfurfuraldehyde (HMF) using microorganisms. Microorganisms were isolated from the soil samples and evaluated for its biotransformation eﬃciency. Among the isolates, Aspergillus ﬂavus APLS-1 was found to be potent for eﬃcient conversion of HMF to FDCA. The bioconversion parameters were optimized by Box-Behnken design. The optimization resulted in 67% conversion eﬃciency where 1g/L HMF (8mM) was transformed to 0.83g/L (6.6mM) FDCA in 14days at pH6.5 with biomass size of 5.7g/L and biomass age 60h. This is the ﬁrst report on Aspergillus sp., capable of detoxifying HMF and produces FDCA.
URI:	https://www.sciencedirect.com/science/article/pii/S0960852419304687 http://10.10.100.66:8080/xmlui/handle/123456789/3486
Appears in Collections:	2019

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