Tandem alpha-Arylation/Cyclization of 4-Haloacetoacetates with Arynes: A Metal-Free Approach toward 4-Aryl-3-(2H)-furanones

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Title:	Tandem alpha-Arylation/Cyclization of 4-Haloacetoacetates with Arynes: A Metal-Free Approach toward 4-Aryl-3-(2H)-furanones
Authors:	J, John V K, Omanakuttan T, Aneeja C H, Suresh P G, Jones H, Hopf
Keywords:	Furanones Ring closing
Issue Date:	4-Apr-2019
Publisher:	American Chemical Society
Citation:	The Journal of Organic Chemistry; 84(9):5957-5964
Abstract:	An efficacious, metal-free strategy has been developed for the synthesis of 4-aryl-3-(2H)-furanones. The reaction proceeds via the nucleophilic addition of an active methylene compound to the aryne followed by ring closing of the adduct. The reaction proceeds under mild conditions, is applicable for gram-scale synthesis of 4-aryl-3-(2H)-furanones, and is general for a range of substituted arynes and ring closing
URI:	https://pubs.acs.org/doi/pdf/10.1021/acs.joc.9b00488 http://10.10.100.66:8080/xmlui/handle/123456789/3571
Appears in Collections:	2019

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