I-2/tbhp Mediated Diastereoselective Synthesis of Spiroaziridines

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Title:	I-2/tbhp Mediated Diastereoselective Synthesis of Spiroaziridines
Authors:	Ashitha, K T Vinaya, P P Krishna, A Vincent, D C Jalaja, R Varughese, S Somappa, S B
Keywords:	TBHP diastereoselective spiroaziridines
Issue Date:	4-Feb-2020
Publisher:	Royal Society of Chemistry
Citation:	Organic & Biomolecular Chemistry; 18(8):1588-1593
Abstract:	Eventhough spiroheterocycles are considered as emerging drug candidates, synthesis of spiroaziridines has not been well explored so far. Herein, we disclose an efficient I2/TBHP mediated diastereoselective synthesis of N-alkyl spiroaziridines from primary amines and easily accessible α,β-unsaturated ketones. The reaction is also compatible for the synthesis of 2-aroylaziridines.
URI:	https://pubs.rsc.org/en/content/articlepdf/2020/ob/c9ob02711d http://hdl.handle.net/123456789/3701
Appears in Collections:	2020

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