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dc.contributor.authorRavindran, J-
dc.contributor.authorYadhukrishnan, VO-
dc.contributor.authorAsha, RS-
dc.contributor.authorLankalapalli, RS-
dc.date.accessioned2021-05-14T06:55:56Z-
dc.date.available2021-05-14T06:55:56Z-
dc.date.issued2020-
dc.identifier.citationOrganic & Biomolecular Chemistry;18(20):3927-3937.en_US
dc.identifier.urihttps://doi.org/10.1039/d0ob00721h-
dc.identifier.urihttp://hdl.handle.net/123456789/3764-
dc.description.abstractMulticomponent reactions (MCRs) using dienaminodioate with post-benzylic oxidative transformation mediated by DDQ that afforded a diverse array of products are described. An unprecedented rearrangement of 1,2-dihydropyridines (1,2-DHPs), 3CR products, to 2-pyridones in good yields with a broad substrate scope by DDQ-mediated benzylic oxidation via a pyridinium intermediate is reported. Treatment of the pyridinium intermediate with tert-butyl isocyanide afforded isomerized 1,2-DHPs, analogous to Ritter amides. Further diversification using 3CR products bearing a benzylic group, predictably, promoted the synthesis of 2-pyridone with a benzylideneamine group and a benzo[d]oxazole appended biaryl group by DDQ. A formal 1,6-reduction product from 2-pyridone in the presence of NaBH4 is also observed.en_US
dc.language.isoenen_US
dc.publisherRoyal Society of Chemistryen_US
dc.subjectdienaminodioateen_US
dc.subjectpost-benzylicen_US
dc.subjectDDQen_US
dc.titleDienaminodioate Based Multicomponent Reactions with Post-Benzylic Oxidative Transformations Mediated by DDQen_US
dc.typeArticleen_US
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