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Title: Novel Pyrazolyl-Thiazoles: Synthesis, Characterization and Study of their Antidiabetic Properties
Authors: Ningaiah, S
Bhadraiah, UK
Basavanna, V
Lingegowda, NS
Shanthakumar, DC
Doddamani, S
Keywords: pyrazole-4-carboxylic acid
in vitro antidiabetic
pi-amylase and pi-glucosidase
Issue Date: 18-Apr-2020
Publisher: AMG Transcend Association
Citation: Biointerface Research in Applied Chemistry;10(4):5849-5854
Abstract: A novel series of 1,3-diphenyl-pyrazole-4-carboxylic acid and its thiazole derivatives were conveniently synthesized followed by coupling reaction to investigate their efficiency as α-amylase and α-glucosidase inhibiting agents. Initially, pyrazole esters were obtained by using various benzaldehydes as precursor and subsequently converted to respective acids in tetrahydrofuran solvent medium. All the acid key intermediates obtained were coupled with previously synthesized thiazole amines to yield title compound with good yield. The current attempt cultivated many advantages such as good yield, time quenching and easy work up. Structures of newly obtained compounds were characterized by spectral studies such as NMR, Mass, IR and elemental analytical techniques. Finally, all the prepared compounds were tested for their antidiabetic activity. Among the synthesized compounds in comparison with standard drug, compound 4c, 4e and 4j showed promising in vitro antidiabetic activity. Bioassay result suggest that the compound 4e may emerge as a potent antidiabetic agent in future drug design.
Appears in Collections:2020

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