Spice-infused palmyra palm syrup improved cell-mediated immunity in wistar albino rats

Abstract

Spices attract tremendous attention in the management of viral infections. However, scientific validation is vital to recommend spices as nutraceuticals or functional foods. In the present work, we have selected three spices based on Ayurvedic knowledge and developed a nutraceutical for immunomodulation. Trikatu, a blend of ginger, black pepper, and long pepper, is used in the Indian Ayurvedic system, along with many herbs, for various ailments. We formulated a “Trikatu syrup” (TS) using these three spices and palmyra palm neera. Carbon clearance assay, neutrophil adhesion test, and sheep red blood cell (SRBC)‐induced delayed‐type hypersensitivity (DTH) reaction was performed to investigate the immunomodulatory potential of TS in Wistar Albino rats. The rats fed with TS showed a dose‐dependent increase in footpad thickness compared to control rats, suggesting cell‐mediated immunity. The major bioactive piperine in TS was isolated and quantified.