Please use this identifier to cite or link to this item: http://hdl.handle.net/123456789/3885
Title: Antiproliferative labdane diterpenes from the rhizomes of Hedychium flavescens Carey ex Roscoe
Authors: Subramanyan, S
Deepika, S
Ajith, A
Gracy, A J
Dan, M
Maiti, K K
Luxmi Varma, R
Radhakrishnan, K V
Issue Date: Oct-2021
Publisher: Wiley
Citation: Chemical Biology & Drug Design; 98(4): 501-506.
Abstract: Antiproliferative activity was confirmed in the various extracts of rhizomes of Hedychium flavescens (Zingiberaceae). The phytochemical investigation of the rhizomes of Hedychium flavescens led to the isolation of four labdane diterpenes. Their structures were established as coronarin E (1), C-14 epimers of isocoronarin D (2), C-15 epimers of coronarin D methyl ether (3) and isocoronarin D (4). The structure of the compounds was identified based on spectroscopic analysis and on comparison with literature reports. All these compounds were assessed for their in vitro cytotoxicity against human lung adenocarcinoma (A549) cell line and showed significant cytotoxicity as reflected in IC50 value, that is, 0.52, 0.59, 0.68 and 1.22 μM compared with the control doxorubicin (IC50 0.92 μM). Moreover, all the compounds were nontoxic towards the normal lung fibroblast (WI-38) cells. The chemo-profiling and cytotoxicity study of Hedychium flavescens is reported for the first time.
URI: https://onlinelibrary.wiley.com/doi/full/10.1111/cbdd.13906
http://hdl.handle.net/123456789/3885
Appears in Collections:2021



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.