Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/3901
Title: Metabolic Circuits and Gene Regulators in Polyhydroxyalkanoate Producing Organisms: Intervention Strategies for Enhanced Production
Authors: Sindhu, R
Madhavan, A
Arun, K B
Pugazhendhi, A
Reshmy, R
Awasthi, MK
Sirohi, R
Tarafdar, A
Pandey, A
Binod, P
Keywords: polyhydroxyalkanoates
metabolic engineering
synthetic biology
transcription regulators
Issue Date: May-2021
Publisher: Elsevier
Citation: Bioresource Technology; 327: 124791
Abstract: Worldwide worries upsurge concerning environmental pollutions triggered by the accumulation of plastic wastes. Biopolymers are promising candidates for resolving these difficulties by replacing non-biodegradable plastics. Among biopolymers, polyhydroxyalkanoates (PHAs), are natural polymers that are synthesized and accumulated in a range of microorganisms, are considered as promising biopolymers since they have biocompatibility, biodegradability, and other physico-chemical properties comparable to those of synthetic plastics. Consequently, considerable research have been attempted to advance a better understanding of mechanisms related to the metabolic synthesis and characteristics of PHAs and to develop native and recombinant microorganisms that can proficiently produce PHAs comprising desired monomers with high titer and productivity for industrial applications. Recent developments in metabolic engineering and synthetic biology applied to enhance PHA synthesis include, promoter engineering, ribosome-binding site (RBS) engineering, development of synthetic constructs etc. This review gives a brief overview of metabolic routes and regulators of PHA production and its intervention strategies.
Appears in Collections:2021

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