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Title: Amphiphilic Fluorescent Probe Self-encored in Plasma to Detect PH Fluctuations in Cancer Cell Membranes
Authors: Podder, A
Joseph, MM
Biswas, S
Samanta, S
Maiti, KK
Bhuniya, S
Keywords: pH fluctuations
cancer cell membrane
tumor spheroids
absorption spectroscopy
Issue Date: 2021
Publisher: Royal Society of Chemistry
Citation: Chemical Communications; 57(5): 607-610
Abstract: We have developed an amphiphilic pH probe (P1CS) to detect pH levels in the plasma membrane in cancer cells. An elevated fluorescence signal at 550 nm at the cell surface of cancer cells (MDA-MB-231, HeLa cells) prompted the application of P1CS as a pH marker for the cancer cell surface, discriminating it from normal cells (WI-38). Moreover, the probe enables labeling of the surface of multilayered tumor spheroids, which promotes its use as a marker for the surface of tumor tissue.
Appears in Collections:2021

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