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dc.contributor.authorAnaga, N-
dc.contributor.authorBasavaraja, D-
dc.contributor.authorAbraham, B-
dc.contributor.authorNisha, P-
dc.contributor.authorVarughese, S-
dc.contributor.authorJayamurthy, P-
dc.contributor.authorSasidhar, B S-
dc.date.accessioned2022-02-03T04:38:23Z-
dc.date.available2022-02-03T04:38:23Z-
dc.date.issued2020-12-
dc.identifier.citationBioorganic Chemistry;105:104375en_US
dc.identifier.urihttps://doi.org/10.1016/j.bioorg.2020.104375-
dc.identifier.urihttp://hdl.handle.net/123456789/3971-
dc.description.abstractAdvanced glycation end products (AGEs) are implicated to be the key players in most of the diabetic complications. The AGE’s interfere with the proteins heterogeneously, thereby rendering denaturation and the consequent loss of function and accumulation. Thus, a novel natural product inspired indeno[2,1-c]pyridinone (4a-4ad) molecular templates with AGE’s trapping potential was designed through scaffold hopping approach and synthesized via facile two-step synthetic route. Amongst the tested indeno[2,1-c]pyridinone hybrids, 4i, 4x and 4aa exhibited excellent efficiency in trapping the AGE’s. The percentage of antiglycation is measured by the analytical model system, i.e. via MG trapping capacity; here the compounds 4i, 4x and 4aa with 50.03%, 69.58%, and 93.37% respectively has displayed promising efficiency. In particular, 4aa demonstrated better activity than the positive control aminoguanidine (79.82%). The in-vitro toxicity of compounds was tested on L6 rat skeletal muscle cell lines revealed that none of the compounds showed any significant toxicity at concentrations up to 1000 μM.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectglycation end-productsen_US
dc.subjectmetabolic disordersen_US
dc.subjectAGE inhibitorsen_US
dc.subjectindeno[2,1-c]pyridinonesen_US
dc.subjectmethylglyoxal trappingen_US
dc.titleAdvanced Glycation End-products (AGE) Trapping Agents: Design and Synthesis of Nature Inspired Indeno[2,1-c]Pyridinonesen_US
dc.typeArticleen_US
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