Please use this identifier to cite or link to this item: http://localhost:8080/xmlui/handle/123456789/4133
Title: Nanohybrids of Magnetically Intercalated Optical Metamaterials for Magnetic Resonance/Raman Imaging and In Situ Chemodynamic/Photothermal Therapy
Authors: Jibin, K
Victor, M
Saranya, G
Santhakumar, H
Murali, V
Maiti, K K
Jayasree, R S
Keywords: plasmonic hybrid
Fenton reaction
magnetic resonance imaging
surface-enhanced Raman scattering
superparamagnetic iron oxide nanoparticles
Issue Date: 19-Jul-2021
Publisher: ACS Publications
Citation: ACS Applied Bio Materials;4(7):5742-5752
Abstract: Target-specific reactive oxygen species (ROS)-based cancer treatments with high therapeutic efficacy and minimal side effects have been identified recently as a potentially effective cancer management strategy. Herein, we report the fabrication of a targeted nanotheranostic agent built on an iron oxide nanoparticle-decorated graphene−gold hybrid [plasmonic magnetic nanoprobe (PMNP)] for self-guided magnetic resonance (MR)/surface-enhanced Raman scattering imaging and photothermal therapy (PTT)/chemodynamic therapy (CDT). In the presence of glutathione, which is abundant in the tumor environment, the iron oxide nanoparticles undergo in situ reduction, which in turn generates hydroxyl radicals via a Fenton reaction to realize targeted destruction of tumor cells. Moreover, the localized production of heat benefited from the near-infrared absorption of the PMNP accelerates the intratumoral ROS generation process, with a synergistic effect of CDT/PTT. Furthermore, the probe offers an accurate visualization of the intracellular localization of the material through SERS/MR dual imaging channels. In view of the advantages offered by the tumor-specific stimuli-responsive nature of the probe, the PMNP presents as an effective tool for cancer management.
Appears in Collections:2021

Files in This Item:
File Description SizeFormat 
Nanohybrids of Magnetically Intercalated Optical Metamaterials _jibin_ACS Applied bio materials.pdf
  Restricted Access
9.98 MBAdobe PDFView/Open Request a copy

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.