Synthesis of 3(2H)‐Furanones: A Review

Abstract

The present review describes the methods reported for the synthesis of 3(2H)-furanones. This heterocycle forms the core structure of a number of natural products and biologically active scaffolds. We have covered all reports available on the synthesis of 3(2H)-furanone derivatives and have divided the review into several sections based on the substitution patterns present in the heterocycle. Special emphasis is given to the generality and the mechanistic rationalizations of each methodology. In addition, all total syntheses reported for the synthesis of 3(2H)-furanone containing natural products are reviewed by highlighting the heterocycle synthesis.